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Rhodium-catalysed racemisation of N-acyl α-amino acids

✍ Scribed by Martin J Hateley; Daniel A Schichl; Hans-Jörn Kreuzfeld; Matthias Beller

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
157 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first transition metal-catalysed racemisation of N-acyl α-amino acids, which is of importance for kinetic resolution processes, is described. Enantiomerically pure N-acyl α-amino acids were efficiently racemised under mild conditions using various rhodium complexes as catalysts, e.g. [Rh(cod)Cl] 2 , in the presence of phosphines.

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