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Rhodium-Catalysed Intermolecular Alkyne Hydroacylation: The Enantioselective Synthesis of α- and β-Substituted Ketones by Kinetic Resolution

✍ Scribed by Dr. Carlos González-Rodríguez; Scott R. Parsons; Dr. Amber L. Thompson; Dr. Michael C. Willis

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
212 KB
Volume
16
Category
Article
ISSN
0947-6539

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ChemInform Abstract: Rhodium-Catalyzed I
ChemInform Abstract: Rhodium-Catalyzed Intermolecular Alkyne Hydroacylation: The Enantioselective Synthesis of α- and β-Substituted Ketones by Kinetic Resolution.
✍ Carlos Gonzalez-Rodriguez; Scott R. Parsons; Amber L. Thompson; Michael C. Willi 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 69 KB 👁 1 views

## Abstract The Rh‐catalyzed asymmetric addition of α‐ (VII) or β‐substituted S‐chelating aldehydes (I), (V) towards terminal alkynes (II) is successfully used as kinetic resolution procedure to afford the corresponding α‐ and β‐substituted enones in up to 90% optical purity.