Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

Long-term modulation of glucose utilizat

Long-term modulation of glucose utilization by IL-1α and TNF-α in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms

✍ Céline Véga; Luc Pellerin; Robert Dantzer; Pierre J. Magistretti 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB

Interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha) markedly stimulate glucose utilization in primary cultures of mouse cortical astrocytes. The mechanism that gives rise to this effect, which takes place several hours after application of cytokine, has remained unclear. Exper