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RhoC Promotes Human Melanoma Invasion in a PI3K/Akt-Dependent Pathway

✍ Scribed by Ruth, Mariah C; Xu, Yisheng; Maxwell, Ian H; Ahn, Natalie G; Norris, David A; Shellman, Yiqun G

Book ID
110049288
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
200 KB
Volume
126
Category
Article
ISSN
0022-202X

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of