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Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction

✍ Scribed by Ming-Ho Tsai; Meei Jyh Jiang


Publisher
Springer
Year
2006
Tongue
English
Weight
288 KB
Volume
453
Category
Article
ISSN
0031-6768

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In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0