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Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: Regulation of the p38 MAP kinase pathway

✍ Scribed by Kondo, Akira; Tokuda, Haruhiko; Matsushima-Nishiwaki, Rie; Kuroyanagi, Gen; Yamamoto, Naohiro; Mizutani, Jun; Kozawa, Osamu; Otsuka, Takanobu


Book ID
121431600
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
856 KB
Volume
96
Category
Article
ISSN
0024-3205

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✍ Osamu Kozawa; Daijiro Hatakeyama; Toshihiko Uematsu πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 153 KB

## Abstract In the present study, we investigated whether the mitogen‐activated protein (MAP) kinase superfamily is involved in the bone morphogenetic protein (BMP)‐4‐stimulated synthesis of osteocalcin in osteoblast‐like MC3T3‐E1 cells. BMP‐4 dose‐dependently stimulated osteocalcin synthesis. BMP‐