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Rho-Kinase Inhibition Suppresses Potassium Chloride-Induced Bladder Hyperactivity in a Rat Model

✍ Scribed by Mahadevan Rajasekaran; Neal Mehta; Angelo Baquir; Steven Kuntz


Book ID
116947325
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
269 KB
Volume
69
Category
Article
ISSN
0090-4295

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Rho-kinase inhibition suppresses bladder
✍ Mahadevan Rajasekaran; Nathan Wilkes; Steven Kuntz; Michael E. Albo πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 240 KB

## Abstract ## Aims Spontaneously hypertensive rats (SHR) exhibit overactive bladder (OAB) symptoms and have an up‐regulated calcium sensitizing RhoA/Rho‐kinase pathway in their vascular smooth muscle tissues. This study examined the role of RhoA/Rho‐kinase pathway in bladder hyperactivity by eval