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Rho-dependent transcriptional activation of the murine cyclooxygenase-2 promoter by GRP

✍ Scribed by Lee W. Slice; Enrique Rozengurt; John H. Walsh

Book ID: 119425917
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 345 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(00)82797-3

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## Abstract Previously, we demonstrated that the gastrin releasing peptide (GRP) induces cyclooxygenase‐2 (COX‐2) expression through a Rho‐dependent, protein kinase C (PKC)‐independent signaling pathway in fibroblasts (Slice et al., 1999, J Biol Chem 274:27562–27566). However, the specific role of

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