Rheumatoid arthritis risk allele PTPRC is also associated with response to anti–tumor necrosis factor α therapy
✍ Scribed by Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H. M. van der Helm-Van Mil; Joanne Nititham; Laura B. Hughes; Niek de Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Sara Wedrén; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J. Bart A. Crusius; Irene E. van der Horst-Bruinsma; Marieke Herenius; Michael E. Weinblatt; Nancy A. Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Kimme Hyrich; Michael F. Seldin; Larry W. Moreland; Timothy W. Behrens; Cornelia F. Allaart; Lindsey A. Criswell; Tom W. J. Huizinga; Paul P. Tak; S. Louis Bridges Jr.; Rene E. M. Toes; Anne Barton; Lars Klareskog; Peter K. Gregersen; Elizabeth W. Karlson; Robert M. Plenge
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 237 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0004-3591
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## Objective Several rheumatoid arthritis (RA) susceptibility variants map close to genes involved in the tumor necrosis factor (TNF) signaling pathway, prompting the investigation of RA susceptibility variants in studies of predictors of response to TNF blockade. Based on a previously reported ass
## Abstract ## Objective To assess the association between the initiation of anti–tumor necrosis factor α (anti‐TNFα) therapy and the risk of serious bacterial infections in routine care. ## Methods This was a cohort study of patients with rheumatoid arthritis (RA) in whom specific disease‐modif