Rheumatoid arthritis in a United States Public Health Service Hospital in Oklahoma. Serologic manifestations in rheumatoid arthritis vary among tribal groups
✍ Scribed by R. Hal Scofield; Mark Fogle; Everett R. Rhoades; John B. Harley
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 374 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
To study the serologic manifestations of rheumatoid arthritis (RA) at a United States Public Health Service Hospital that serves numerous tribes in Oklahoma.
Methods. Forty-five patients with RA were identified, and serologic studies for antinuclear antibody (ANA), rheumatoid factor, and antibodies to extractable nuclear antigens were performed. Extraarticular manifestions of RA were also evaluated.
Results. Twelve of the 45 patients with RA were Kiowa. These patients were significantly more likely to have a positive ANA (75%) than the other patients with RA (28%). In addition, anti-Ro was significantly more common among Kiowa (33%) than among members of other tribes (3%). There was no difference in the extraarticular manifestions of the Kiowa compared with the other Native American tribes.
Conclusion. RA can be distinctly characterized by serology among groups of American Indians living in the same geographic area.
Rheumatoid arthritis (RA) produces chronic, destructive articular disease that is characterized as symmetrical and erosive. The metacarpophalangeal joints are typically affected, but almost any joint may be involved. The disease is worldwide in distribution and affects about 1% of the population (1); however, RA is likely of recent origin in the Old World. The first