𝔖 Scriptorium
✦   LIBER   ✦

πŸ“

Rheumatoid Arthritis

✍ Scribed by Marc C. Hochberg MD MPH, Alan J. Silman MD, Josef S. Smolen MD, Michael E. Weinblatt MD, Michael H. Weisman MD


Publisher
Mosby
Year
2008
Tongue
English
Leaves
449
Edition
1
Category
Library

⬇  Acquire This Volume

No coin nor oath required. For personal study only.

✦ Synopsis


First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It's the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease.Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures-disease activity, joint assessment, imaging, and more-for expert diagnosis and monitoring of disease progression.Examines evidence-based treatment options-including traditional and biologic DMARDs and combination therapies-as well as promising therapies on the horizon, placing up-to-date guidance on disease modifying or disease controlling agents at your fingertips.

✦ Table of Contents


RHEUMATOID ARTHRITIS......Page 1
Copyright Β© 2009 by Mosby, Inc., an affiliate of Elsevier Inc.......Page 2
Dedication......Page 3
Foreword......Page 4
REFERENCES......Page 5
Contributors......Page 7
Acknowledgments......Page 12
CHAPTER 1 - Classification Criteria......Page 13
CHAPTER 2 - Descriptive Epidemiology of Rheumatoid Arthritis......Page 26
CHAPTER 3A - The Genetic Basis of Rheumatoid Arthritis......Page 34
CHAPTER 3B - Environmental Risk Factors for Rheumatoid Arthritis......Page 39
CHAPTER 3C - Risk Factors for Rheumatoid Arthritis: Other Nongenetic Host Factors......Page 46
CHAPTER 4 - The Onset of Rheumatoid Arthritis......Page 52
CHAPTER 5A - Articular and Periarticular Manifestations of Established Rheumatoid Arthritis......Page 60
CHAPTER 5B - Clinical Features of Rheumatoid Arthritis: Extra-Articular Manifestations......Page 73
CHAPTER 5C - Comorbidity in Rheumatoid Arthritis......Page 79
CHAPTER 6 - Early (Rheumatoid) Arthritis......Page 83
CHAPTER 7 - The Social and Economic Impact of Rheumatoid Arthritis......Page 92
CHAPTER 8A - The Role of T Cells in Rheumatoid Arthritis......Page 99
CHAPTER 8B - The Role of B Cells in Rheumatoid Arthritis......Page 105
CHAPTER 8C - Macrophages......Page 115
CHAPTER 8D - Dendritic Cells......Page 124
CHAPTER 8E - Mast Cells......Page 132
CHAPTER 8F - Synovial Fibroblasts: Important Players in the Induction of Inflammation and Joint Destruction......Page 144
CHAPTER 8G - Chondrocytes: Pathogenesis of Rheumatoid Arthritis......Page 159
CHAPTER 8H - Osteoclasts and Osteoblasts......Page 171
CHAPTER 8I - Endothelial Cells and Angiogenesis......Page 176
CHAPTER 8J - Autoantibodies: Diagnostic Helpers and Pathogenetic Players......Page 188
CHAPTER 8K - Complement in Rheumatoid Arthritis......Page 199
CHAPTER 8L - Pathogenesis in Rheumatoid Arthritis: Cytokines......Page 208
CHAPTER 8M - Signal Transduction......Page 217
CHAPTER 8N - Animal Models......Page 226
CHAPTER 9A - Outcome Measurement in Rheumatoid Arthritis: Disease Activity......Page 233
CHAPTER 9B - Physical Function......Page 239
CHAPTER 8C - Health-Related Quality of Life in Rheumatoid Arthritis......Page 245
CHAPTER 9D - Radiography......Page 268
CHAPTER 9E - Sonography......Page 275
CHAPTER 9F - Outcome Measurement in Rheumatoid Arthritis: Magnetic Resonance Imaging......Page 283
CHAPTER 9G - Physical Examination......Page 287
CHAPTER 9H - Pharmacoeconomic Aspects of Rheumatoid Arthritis Management......Page 293
CHAPTER 9I - Synovial Biomarkers......Page 297
CHAPTER 10A - Nonsteroidal Anti-Inflammatory Drugs and Coxibs......Page 303
CHAPTER 10B - Glucocorticoids......Page 308
CHAPTER 10C - Methotrexate: The Foundation of Rheumatoid Arthritis Therapy......Page 315
CHAPTER 10D - Leflunomide......Page 323
CHAPTER 10E - Other Traditional Disease-Modifying Antirheumatic Drugs: Monotherapy and Combination Therapy......Page 333
CHAPTER 10F - Treatment of Rheumatoid Arthritis: Tumor Necrosis Factor Inhibitors......Page 345
CHAPTER 10G - IL-1 Inhibitors in the Treatment of Rheumatoid Arthritis......Page 358
CHAPTER 10H - Abatacept......Page 364
CHAPTER 10I - Rituximab......Page 370
CHAPTER 10J - Tocilizumab......Page 375
CHAPTER 10K - Promising Biologic Agents and Small Chemical Compounds......Page 380
CHAPTER 10L - Infections and Rheumatoid Arthritis: Old Bugs and New Drugs......Page 387
CHAPTER 11A - Design of Trials for New Therapies in Patients with Rheumatoid Arthritis......Page 395
CHAPTER 11B - What Should Be Reported in Clinical Trials?......Page 402
CHAPTER 11C - Regulatory View: U.S. Food and Drug Administration......Page 411
CHAPTER 11D - Ethics in Clinical Trials......Page 421
CHAPTER 12A - European Biologics Registers......Page 427
CHAPTER 12B - Registries in Rheumatic Disease Epidemiology......Page 435
Index......Page 443


πŸ“œ SIMILAR VOLUMES


Rheumatoid Arthritis
✍ E. William St. Clair, David S. Pisetsky, Barton F. Haynes πŸ“‚ Library πŸ“… 2004 πŸ› Lippincott Williams & Wilkins 🌐 English

<DIV>This authoritative clinical reference provides comprehensive coverage of all aspects of rheumatoid arthritis. The basics of rheumatoid arthritis are thoroughly covered in order to provide a firm foundation for the main focus of the text: therapy and clinical management of the disease. Practitio

Rheumatoid Arthritis
✍ Michael H. Weisman πŸ“‚ Library πŸ“… 2011 πŸ› Oxford University Press 🌐 English

Rheumatoid arthritis is a common but often debilitating disorder. Given the intricate and challenging nature of treating rheumatoid arthritis, it is imperative to educate physicians on the disease's initial symptoms and complications, as well as to provide accurate and up-to-date information regardi

Arthritis: About osteoarthritis and rheu
✍ Anthony Di Fabio, Gus J. Prosch πŸ“‚ Library πŸ“… 1997 πŸ› Arthritis Trust of America 🌐 English

Affecting tens of millions of people, osteoarthritis and rheumatoid disease, including rheumatoid arthritis, is treatable and curable, according to authors. Describes what’s wrong with traditional treatments, and details successful treatments used by hundreds of doctors. True case histories of succe

Understanding Rheumatoid Arthritis
✍ Ray Fitzpatrick πŸ“‚ Library πŸ“… 1995 🌐 English

Rheumatoid arthritis (RA) is a major cause of disability affecting about 1% of the population. Although much effort has been expended on research into the causes and cures of RA, little progress has been made. The focus of treatment in RA is on reducing the disabling consequences of the disease and

Rheumatoid Arthritis, 2004
✍ E. William St. Clair, David S Pisetsky, Barton F Haynes, πŸ“‚ Library πŸ“… 2004 πŸ› Lippincott Williams & Wilkins 🌐 English

This authoritative clinical reference provides comprehensive coverage of all aspects of rheumatoid arthritis. The basics of rheumatoid arthritis are thoroughly covered in order to provide a firm foundation for the main focus of the text: therapy and clinical management of the disease. Practitioners

Rheumatoid Arthritis FAQs
✍ Eric Newman; Cynthia Matzko πŸ“‚ Library πŸ“… 2007 πŸ› B. C. Decker Incorporated 🌐 English