Rheology of gelatin films

✍ Scribed by Robert A. Castello; Jere E. Goyan

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 535 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530717

✦ Synopsis

doses. The depressor effect of the esters was similar in cats and rabbits. It could not be blocked by atropine, and it could be reversed by epinephrine. This was indicative that the effect was due to direct smooth muscle relaxation or to the cardiac depression which was quite apparent.

To show that the depressor effect was primarily due to cardiac inhibition, the esters were tested on the isolated rabbit heart after the method of Langendorff (11). As can be seen in Fig. 4, all of the compounds brought about a sharp decline in both rate and amplitude of the heart beat. If given in carefully controlled doses, the heart returned to normal, but higher doses resulted in complete heart arrest. Coronary flow was also markedly diminished, precluding the possibility of significant direct smooth muscle relaxation.