RGTA OTR4120, a heparan sulfate mimetic, is a possible long-term active agent to heal burned skin
✍ Scribed by S. Garcia-Filipe; V. Barbier-Chassefiere; C. Alexakis; E. Huet; D. Ledoux; M. E. Kerros; E. Petit; D. Barritault; J. P. Caruelle; P. Kern
- Book ID
- 102294145
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 160 KB
- Volume
- 80A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Burn‐related skin fibrosis leads to loss of tissue function and hypertrophic scar formation with damaging consequences for the patient. There is therefore a great need for an efficient agent to treat burned skin. We report that ReGeneraTing Agent (RGTA) reduces burn‐induced skin alteration. The tissue‐regenerating effect of RGTA OTR4120 was evaluated after 1–6 days and after 10 months in a rat skin burn model. This effect was also examined in vitro using fibroblasts isolated from control and 6‐day‐old burned skins. We measured production of dermal collagen I, III, and V and activities of metalloproteinases 2 and 9 (MMP‐2 and MMP‐9). Ratio of collagen III over collagen I production increased 6 days after the burn, because of a decrease in collagen I production. After 10 months, ratio of collagen III over collagen I in burn sites was still increased compared with control skin, because of an increase in collagen III production. Both abnormalities were corrected by OTR4120. OTR4120 increased pro‐ and active MMP‐2 and MMP‐9, compared with healthy and burned controls and therefore accelerated remodeling. Similar data were obtained with cultured fibroblasts from healthy and burned skins. OTR4120 enhanced healing in short‐ and long‐term after burns, reducing the formation of fibrotic tissue, and then represents a potential agent to improve burned skin healing. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007