Revision of the Absolute Configuration at C(23) of Lanostanoids and Isolation of Secondary Metabolites from Formosan Soft Coral Nephthea erecta
✍ Scribed by Shi-Yie Cheng; Zhi-Hong Wen; Shang-Kewi Wang; Michael Y. Chiang; Ali A. H. El-Gamal; Chang-Feng Dai; Chang-Yih Duh
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 274 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1612-1872
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✦ Synopsis
Abstract
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Three new oxygenated ergostanoids, 1–3, one known ergostanoid, 4, one new trinoreudesmadienone, 5, one new calamenene type sesquiterpene, 6, and one known aristolane‐type sesquiterpene, (−)‐aristolone (7), have been isolated from the AcOEt extract of the soft coral Nephthea erecta. The structures of these compounds were determined by extensive spectroscopic and X‐ray crystallographic analysis, as well as Mosher's method. We revised the absolute configuration at C(23) in the side chain of some lanostanoids as a result of the Mosher's products of 1 (i.e., 1a and 1b). The cytotoxicities against selected cancer cells and the anti‐inflammatory effects of these tested metabolites 1–7 were determined in vitro.