Revising messages traveling along the cellular information superhighway

✍ Scribed by Bruce A. Sullenger

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 754 KB
• Volume: 2
• Category: Article
• ISSN: 1074-5521
• DOI: 10.1016/1074-5521(95)90043-8

✦ Synopsis

BRUCE A SULLENGER

CROSSTALK

Revising messages traveling along the cellular information superhighway

Cells use RNA messages to carry instructions from the genome to ribosomes about the types of proteins that should be made. These messages are generally revised by splicing before translation.

Engineering ribozymes that can use splicing to repair mutant transcripts may be a useful approach to gene therapy of several genetic diseases.