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Review of Ionic Models of Vagal-Cardiac Pacemaker Control

✍ Scribed by Socrates Dokos; Nigel H. Lovell; Branko G. Celler

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 212 KB
Volume: 192
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.1997.0619

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✦ Synopsis

Mathematical models of ion currents in pacemaker cells of the heart and their associated modulation by vagal stimulation have provided numerous insights into the ionic mechanisms underlying parasympathetic control of heart rate. In this article, ionic models described in the literature are reviewed and compared, with a view to examining their effectiveness in reproducing known chronotropic responses to vagal stimulation.

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