Review of attempts to induce lung cancer in experimental animals by tobacco smoke

✍ Scribed by L. M. Shabad

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 560 KB
• Volume: 27
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197101)27:1<51::aid-cncr2820270109>3.0.co;2-x

✦ Synopsis

This is a review of chemical-analytical and biological work undertaken in the U.S.S.R. i n recent years in the area of tobacco and air pollution carcinogenesis. Special emphasis is given to the studies attempting to induce lung cancer in laboratory animals.

LTHOUGH TOBACCO SMOKE CONTAINS TRACE

A amounts of carcinogens18 3 and its particulate matter produces carcinoma in mice and rabbits and sarcomas in rats, passive or active inhalation experiments with mice, rats, hamsters, and dogs have not been able to induce true epidermoid carcinoma of the lung.4

The following discussion reviews studies performed in the U.S.S.R. with tobacco smoke on experimental animals, as well as .other investigations in this same field. Many of the experiments on the carcinogenicity of tobacco products were performed by skin application or subcutaneous injection, with contradictory results. In our laboratory, Shotadzel9 and Kakhian? applied tobacco "tar" obtained with a pipe-like apparatus to mouse skin (150-300 paintings, 50 mg each, for u p to 15 g of "tar" over a one-year period) without inducing either carcinomas or papillomas. Tobacco "tar" applications on the lips of the mice also failed to induce tumors. In Shotadze's experiment, a blend of tobacco from the Lagodekh district of eastern Georgia was used, with about 100 g of "tar" being obtained from 1 kg of the tobacco. A glass flask was connected by glass tubing to a clay vessel containing burning tobacco. T h e smoke was drawn through the glass tube into the flask by the vacuum created by a connecting water pump. The thickest portion of the "tar" condensed 0nt.o the walls of the glass tube while the liquid portion dropped into the flask. For the experimental study, both portions of the "tar" were mixed,

In another experiment, Martynenko applied cigarette "tar" daily onto the mucosa of