## Abstract Colchicine resistant (CH^R^) mutants of CHO cells with reduced permeability to colchicine display extensive crossβresistance to a number of apparently unrelated compounds including puromycin, daunomycin, emetine, ethidium bromide and gramicidin D. A positive correlation was observed bet
Revertants of pleiotropic cross resistance and collateral sensitivity in yeast: A multivariate analysis
β Scribed by Rank, G. H. ;Sheard, J. W.
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 668 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0026-8925
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A mutant strain (2-20) isolated by growth on medium containing oligomycin and cycloheximide was also found to be cross resistant to antimyicn, cerulenin, chloramphenicol, tetracycline, triethyltin and triphenylmethylphosphonium bromide, but collaterally sensitive to dequalinium chloride, gentamycin,
Two sublines were derived from a human bladder carcinoma continuous cell line (RTI 12-P), one by exposure to fractionated X-irradiation (RTI IZ-DXRa) and the other by continuous exposure to cisplatin (RT 112-CP). RTI I2-DXR8 cells were I .6to 2-fold more sensitive to cisplatin and 2 analogues, carbo