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Reversion of the neoplastric phenotype in Ha--transformed rat cells induced by transfection with DNA from normal human cells

✍ Scribed by Schäfer, R.; Iyer, J.; Iten, E.; Nirkko, A.


Book ID
122908799
Publisher
Elsevier Science
Year
1987
Weight
127 KB
Volume
23
Category
Article
ISSN
0277-5379

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Somatic cell hybrids were isolated from fusions of diploid embryonic rat fibroblasts with transformed Rat-1 cells which contained 4 to 5 copies of the transforming human Ha-ras 1 gene. In contrast to their transformed parental cells four hybrid clones showed normal morphology, long latency periods o