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Reversion of sulfenamide prodrugs in the presence of free thiol-containing proteins

โœ Scribed by Nti-Addae, Kwame W. (author);Laurence, Jennifer S. (author);Skinner, Andria L. (author);Stella, Valentino J. (author)

Book ID
102394706
Publisher
John Wiley and Sons Inc.
Year
2011
Tongue
English
Weight
147 KB
Volume
100
Category
Article
ISSN
0022-3549

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In vitro conversion of model sulfenamide
In vitro conversion of model sulfenamide prodrugs in the presence of small molecule thiols
โœ Kwame W. Nti-Addae; Valentino J. Stella ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 369 KB

Sulfenamide prodrugs of amide and urea functional group containing drugs have recently been proposed as a means of altering the physical and bioproperties of problematic drug molecules containing these two functionalities. Sulfenamides have been shown to revert to the parent drug via reaction with t