Naturally occurring dominant resistance
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Thomas Kuntzen; Joerg Timm; Andrew Berical; Niall Lennon; Aaron M. Berlin; Sarah
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Article
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2008
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John Wiley and Sons
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English
β 263 KB
Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease inhibitors in <1% of the viral quasispecies may still allow >1000-fold viral load reductions upon treatment, consistent with their reported reduced replicative fitness in vitro. Recently, however, an R155K proteas