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Reversion of multidrug-resistance by proteasome inhibitor bortezomib in K562/DNR cell line

โœ Scribed by Hui-han Wang; Ying-chun Li; Ai-jun Liao; Bei-bei Fu; Wei Yang; Zhuo-gang Liu; Xiao-bin Wang


Book ID
107467061
Publisher
Chinese Anti-Cancer Association
Year
2011
Tongue
English
Weight
733 KB
Volume
23
Category
Article
ISSN
1000-9604

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We have isolated agosterol A (1) from a marine sponge of Spongia sp. as a reversing substance to multidrug resistance (MDR) in human carcinoma cell lines, KB-C2 and KB-CV60, overexpressing P-glycoprotein and MRP, respectively. Further investigation led us to isolate analogous sterols, agosterols B (