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Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells

โœ Scribed by Aoki, Shunji ;Chen, Zhe-Sheng ;Higasiyama, Kimihiko ;Setiawan, I ;Akiyama, Shin-ichi ;Kobayashi, Motomasa

Book ID
111754252
Publisher
Wiley (Blackwell Publishing)
Year
2001
Tongue
English
Weight
275 KB
Volume
92
Category
Article
ISSN
0910-5050

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We have isolated agosterol A (1) from a marine sponge of Spongia sp. as a reversing substance to multidrug resistance (MDR) in human carcinoma cell lines, KB-C2 and KB-CV60, overexpressing P-glycoprotein and MRP, respectively. Further investigation led us to isolate analogous sterols, agosterols B (

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## We previously isolated agosterol A (AG -A) from a marine Spongia sp. and found that it completely reversed colchicine resistance in P-glycoprotein (Pgp)-over-expressing KB-C2 cells and vincristine resistance in multidrug-resistance protein (MRP)1-over-expressing CV60 cells. However, a tri-deacet