Reversibly Addressing an Allosteric Catalyst In Situ: Catalytic Molecular Tweezers

✍ Scribed by Nathan C. Gianneschi; So-Hye Cho; SonBinh T. Nguyen; Chad A. Mirkin

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 170 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200460932

✦ Synopsis

In biology, allosteric regulation is the control of enzyme activity by the fast, reversible binding of molecules or ions to structural sites that are remote from, but control conformational changes that occur at, the active site. [1] If one considers that reversibility in a biological sense implies in situ control over activity, then there are no known abiotic systems that are truly allosteric catalysts. Recently, the first efforts towards the development of artificial allosteric catalysts have been described. [2,3] Thus far, there have been two distinct approaches to realizing systems that mimic biological allosteric regulation of catalysis. One approach consists of organic [*] N.