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Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

โœ Scribed by Jun Liu; Mary D.H. Nguyen; James D. Andya; Steven J. Shire

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
52 KB
Volume
95
Category
Article
ISSN
0022-3549

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Reversible self-association of a concent
Reversible self-association of a concentrated monoclonal antibody solution mediated by Fabโ€“Fab interaction that impacts solution viscosity
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Reversible self-association of a monoclonal antibody (MAb) in a high concentration formulation results in a solution with a high viscosity. The nature of the self-association of full-length as well as antibody fragments has been studied by rheometry. Chaotropic anions reduced solution viscosity more

Factors affecting the viscosity in high
Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies
โœ Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 372 KB ๐Ÿ‘ 1 views

The viscosity profiles of four different IgG 1 molecules were studied as a function of concentration at pH 6.0. At high concentrations, MAb-H and -A showed significantly higher viscosities as compared to MAb-G and -E. Zeta Potential (j) measurements showed that all the IgG 1 molecules carried a net