Reversible ring-opening of thiamine. Kinetic vs. thermodynamic control of the reclosure
β Scribed by Tee, Oswald S.; Spiropoulos, Georgia D.; McDonald, Robert S.; Geldart, Valerie D.; Moore, David
- Book ID
- 127079141
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 275 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Alprazolam underwent a facile 1,4-benzodiazepine ring-opening reaction in an acidic aqueous solution to form a benzophenone compound. The reaction was demonstrated by means of UV, IR, and 1H- and 13C-NMR spectroscopy. Its reverse cyclization reaction to alprazolam occurred when an acidic solution wa
Diels-Alder cycloaddition of cyclopentadiene (1) to 2,3-dicyano-p-benzoquinone (2), when performed in methanol solvent at ambient temperature (kinetic control), gave 3b. Reduction of 3b, carried out under mild conditions by using CeCI3-NaBH4, proceeded stereospecifically to afford diol $. Subsequent