Reversible Redox Reconfiguration of Secondary Structures in a Designed Peptide
β Scribed by Wang, Xiaojian; Bergenfeld, Irina; Arora, Paramjit S.; Canary, James W.
- Book ID
- 118752164
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 730 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0044-8249
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## Abstract This article describes a strategy to develop, starting from a __de novo__ design, bivalent peptides containing two different (Ξ±βhelix and Ξ²βhairpin) and independent secondaryβstructure elements. The design was based on the use of conformationally restricted peptide libraries. Structural
The incorporation of a-substituted t-amino acids into a tetrapeptide motif induces a reverse turn in aprotic solvent systems as revealed by NOESY and ROESY techniques, and by CD spectra. The conformations of these compounds have been studied by mol ecul ar modeling, and further supported by performi