Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion
โ Scribed by Vikas Kumar; Nailya Kitaeff; Mark B. Hampton; Mark B. Cannell; Christine C. Winterbourn
- Book ID
- 113621251
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 462 KB
- Volume
- 583
- Category
- Article
- ISSN
- 0014-5793
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๐ SIMILAR VOLUMES
## Abstract In conditions of ischemia/reperfusion (I/R), the relative use of all available substrates by the heart has a significant effect on the recovery of the organ. This substrate preference in perfused hearts is influenced by ischemia. We followed the metabolic fate of [Uโ^13^C]glucose and [3
Heme oxygenase (HO) isozymes, HO-1 and HO-2 catalyze the cleavage of heme b to form the antioxidant biliverdin IXa, iron and the putative cellular messenger carbon monoxide (CO). Heat and stress have been reported to induce the expression of HO-1, in analogy to ubiquitin, a protein of 8 kDa involved