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Reversible inhibition of RNA synthesis and irreversible inhibition of protein synthesis by D-galactosamine in isolated mouse hepatocytes

✍ Scribed by J. Mandl; K. Mészáros; F. Antoni; Z. Spolarics; T. Garzó

Publisher
Springer
Year
1982
Tongue
English
Weight
374 KB
Volume
46
Category
Article
ISSN
0300-8177

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✦ Synopsis

The inhibition of RNA synthesis of isolated mouse liver parenchymal cells caused by 10 mM D-galactosamine was reversible, while the inhibition of protein synthesis remained unaltered after the removal of galactosamine. 10(-5)M epinephrine and 10(07)M glucagon have been shown to decrease aminoglycogen formation and thus to reduce the inhibitory effect of galactosamine on protein synthesis (II). However, these hormones did not decrease the inhibition of RNA synthesis. 10 mM D-galactosamine did not effect the nucleoside and amino acid incorporation of isolated non-parenchymal mouse liver cells. The predominant role of aminoglycogen in the inhibition of protein synthesis in galactosamine induced liver injury is discussed.

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