Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease

✍ Scribed by Kleopas A. Kleopa; Kyriacos Kyriacou; Eleni Zamba-Papanicolaou; Theodoros Kyriakides

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 264 KB
• Volume: 31
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.20144

✦ Synopsis

Abstract

We report a patient with late‐onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti‐gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion‐body myositis. A gluten‐free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti‐gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion‐body myopathy in the muscle. Muscle Nerve 2004