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Reversible hypophosphatemic rickets following ifosfamide treatment

✍ Scribed by Van Gool, Stefaan ;Brock, Penelope ;Wijndaele, Godelieve ;van de Casseye, Willy ;Kruger, Marianne ;Proesmans, Willem ;van Daele, Maria Casteels

Book ID
102951097
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
767 KB
Volume
20
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

A 7‐year‐old boy developed renal tubular dysfunction and hypophosphatemic rickets following treatment for relapsed embryonal rhabdomyosarcoma. Multi‐agent chemotherapy included ifosfamide; the child received a total of 108 g/m^2^. The complete Fanconi syndrome which ensued, including excessive loss of calcium, resolved spontaneously and progressively 18 months after the last dose of ifosfamide. The patient had no further symptoms of rickets and radiological signs had almost completely normalized. Further follow‐up was not possible as, despite further treatment, the child died of progressive disease. Β© 1992 Wiley‐Liss, Inc.

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## Abstract Ifosfamide, a nitrogen mustard derived alkylating agent commonly used in the treatment of solid tumors, has been associated with neurotoxicity in 5–33% of treated patients. Encephalopathy most often occurs during or shortly following drug administration, with increased drowsiness or irr