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Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

✍ Scribed by Madhav Dhodapkar; Stuart L. Goldberg; Ayalew Tefferi; Morse A. Gertz

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
172 KB
Volume
45
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.

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