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Reversible decreases of fertility in male Sprague-Dawley rats treated orally with finasteride, a 5Î±-reductase inhibitor

✍ Scribed by David Wise, L.; Minsker, David H.; Cukierski, Mark A.; Clark, Robert L.; Prahalada, Srinivasa; Antonello, Joseph M.; MacDonald, James S.; Robertson, Richard T.

Book ID: 121424816
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 902 KB
Volume: 5
Category: Article
ISSN: 0890-6238
DOI: 10.1016/0890-6238(91)90092-T

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## BACKGROUND. In rats, the prostate is divided into three distinct lobes, and the lobes are dependent on androgens [testosterone (T) and dihydrotestosterone (DHT)] as trophic hormones. However, the reasons for the difference in the incidence of proliferative changes reported are not well-understo