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Reversibility of the inhibition of acetylcholinesterase by tacrine

โœ Scribed by Dawson, Raymond M.


Book ID
121955332
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
289 KB
Volume
118
Category
Article
ISSN
0304-3940

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Binding of tacrine and 6-chlorotacrine b
โœ S. T. Wlodek; J. Antosiewicz; J. A. McCammon; T. P. Straatsma; M. K. Gilson; J. ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 680 KB

Multiconfiguration thermodynamic integration was used to determine the relative binding strength of tacrine and 6-chlorotacrine by Torpedo californica acetylcholinesterase. 6-Chlorotacrine appears to be bound stronger by 0.7+/-0.4 kcal/mol than unsubstituted tacrine when the active site triad residu