Reversed-phase liquid chromatographic method for the analysis of aminoglycoside antibiotics using pre-column derivatization with phenylisocyanate

Development and validation of an improve

Development and validation of an improved reversed-phase liquid chromatographic method combined with pulsed electrochemical detection for the analysis of netilmicin

✍ Vicky Manyanga; Jos Hoogmartens; Erwin Adams 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB

## Abstract Netilmicin is one of the aminoglycoside antibiotics that lacks a strong UV absorbing chromophore. However, the application of pulsed electrochemical detection has been used successfully for the direct analysis of aminoglycoside antibiotics. This study describes an improved LC method com