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Reversed-phase high-performance liquid chromatography (RP-HPLC) determination of lipophilicity of furocoumarins: Relationship with DNA interaction

โœ Scribed by Sergio Caffieri

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
151 KB
Volume
90
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The partition coefยฎcient (P) of 82 furocoumarins and analogs (psoralens, angelicins, allopsoralens, 8-azapsoralens, angular furoquinolin-2-ones, sulfur and selenium isosters of psoralen and angelicin) has been determined by reversed-phase HPLC. The chromatographic behavior correlates well with the in vitro afยฎnity of the compounds toward DNA.

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