Reversed Actrocytic GLT-1 during Ischemia is Crucial to Excitotoxic Death of Neurons, but Contributes to the Survival of Astrocytes themselves

Reversed operation of glutamate transpor

Reversed operation of glutamate transporter GLT-1 is crucial to the development of preconditioning-induced ischemic tolerance of neurons in neuron/astrocyte co-cultures

✍ Koichi Kawahara; Tatsuro Kosugi; Motoki Tanaka; Takayuki Nakajima; Takeshi Yamad 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 848 KB

## Abstract Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study, we investigated the roles of the astrocytic glutamate (Glu) transporter GLT‐1 in preconditioning (PC)‐induced neuronal ischemic tolerance in cortical neuron/astr