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Reverse transcriptase mutations in sequential HIV-1 isolates in a patient with AIDS

✍ Scribed by A. D. Gurusinghe; S. A. Land; C. Birch; C. McGavin; D. J. Hooker; G. Tachedjian; R. Doherty; Dr. N. J. Deacon

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
651 KB
Volume
46
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Sequential human immunodeficiency virus type 1 (HIV‐1) isolates were obtained over a 29‐month period from a person before, during, and after AZT therapy. DNA sequence analysis of polymerase chain‐amplified reverse‐transcriptase gene showed a gradual accumulation of mutations to peak resistance (lC~50~ 2.13 μM AZT) in association with mutations at codons 44, 210, and 369, as well as at 41, 67, 70, and 215. Eight months after cessation of AZT therapy, when an HIV‐1 isolate from the patient was again sensitive to AZT, these mutations had all returned to the pretherapy sequence. © 1995 Wiley‐Liss, Inc.

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