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Reverse Protonation Is the Key to General Acid−Base Catalysis in Enolase †,‡

✍ Scribed by Sims, Paul A.; Larsen, Todd M.; Poyner, Russell R.; Cleland, W. Wallace; Reed, George H.


Book ID
120379593
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
214 KB
Volume
42
Category
Article
ISSN
0006-2960

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✍ Christine L. Hannon; Dwayne A. Bell; Anne M. Kelly-Rowley; Larry A. Cabell; Eric 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 3 views

Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the pK a of the donor is far enough above the pK a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. Ho