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Reverse Brook rearrangement of 2-alkynyl trialkylsilyl ether. Synthesis of optically active (1-hydroxy-2-alkynyl)trialkylsilane

✍ Scribed by Kazuhiko Sakaguchi; Masato Fujita; Hiroyuki Suzuki; Masato Higashino; Yasufumi Ohfune *

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 166 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01086-8

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✦ Synopsis

A new method for the synthesis of optically active a-hydroxyalkynylsilane 3 is described. The key step of the conversion to 3 was the use of the reverse Brook rearrangement of the 2-alkynyl silyl ether 2.

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