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Reversal of Δ9-tetrahydrocannabinol-induced tolerance by specific kinase inhibitors

✍ Scribed by Caroline E Bass; Sandra P Welch; Billy R Martin

Book ID
113584803
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
750 KB
Volume
496
Category
Article
ISSN
0014-2999

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Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next inject