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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

✍ Scribed by Scaffidi, Paola; Misteli, Tom


Book ID
109932353
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
824 KB
Volume
11
Category
Article
ISSN
1078-8956

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Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A