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Reversal of Tamoxifen Resistance (Hormone Resistance) by Addition of Sirolimus (mTOR Inhibitor) in Metastatic Breast Cancer

✍ Scribed by G.S. Bhattacharvva; J. Biswas; J.K. Singh; M. Singh; K. Govindbabu; A.A. Ranade; H. Malhotra; P.M. Parikh; T. Shahid; S. Basu

Book ID: 117660614
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 47 KB
Volume: 47
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(11)70115-0

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## Abstract Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endoc