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Reversal of radiation-induced neutropenia by granulocyte colony-stimulating factor

✍ Scribed by Marks, Lawrence B. ;Friedman, Henry S. ;Kurtzberg, Joanne ;Oakes, W. Jerry ;Hockenberger, Beverly M.


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
237 KB
Volume
20
Category
Article
ISSN
0098-1532

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✦ Synopsis


Abstract

Myelosuppression is a common sequelae of radiotherapy, occasionally delaying the completion of treatment. In this report, we describe successful reversal of radiation‐induced neutropenia in a child receiving craniospinal irradiation by granulocyte colonystimulating factor (G‐CSF). We suggest that G‐CSF be considered as supportive care in patients in whom neutropenia develops during radiotherapy. © 1992 Wiley‐Liss, Inc.


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✍ Saarinen, Ulla M. ;Hovi, Liisa ;Riikonen, Pekka ;Pihkala, Jaana ;Juvonen, Eeva 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 721 KB

## Abstract Twenty children 1–17 (median, 5.5) years of age received GM‐CSF during chemotherapy‐induced neutropenia at the dose of 5 μg/kg/day, continued until the absolute neutrophil count (ANC) exceeded 500 × 10^6^/liter. Twelve children with solid tumors received GM‐CSF after courses of conventi