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Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro

โœ Scribed by K. Schwabe; G. Steinheider; A. Lawen; R. Traber; A. Hildebrandt


Book ID
112498234
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
607 KB
Volume
121
Category
Article
ISSN
1432-1335

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A novel fluorometric microculture cytotoxicity assay (FMCA), based on measurements of fluorescein diacetate (FDA) hydrolysis and DNA staining by Hoechst 33342, was used for drug sensitivity testing and detection of resistance reversal in acute lymphoblastic leukemia (ALL) cell lines. The 72-hr assay