## Abstract In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed the proteomic approach of isobaric tags for relative and absolute quantification (iTRAQ), followed by LCβMS/MS, using the cisplatinβresistant COC1/DDP cell line and its parental
Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene
β Scribed by Huijuan Wu; Danhui Weng; Hui Xing; Yunping Lu; Ding Ma
- Book ID
- 107405690
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- Chinese
- Weight
- 150 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0510-9752
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The cytotoxicity of Doxorubicin and cis-dichloro-diammineplatinum (DDP) was evaluated in clones, obtained from a human ovarian cancer cell line transfected with a ternperaturesensitive p53 mutant, which express mutant p53 at 37Β°C and wild-type-like p53 at 32Β°C. DDP was equally active in cells not ex