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Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene

✍ Scribed by M.C Manara; N Baldini; M Serra; P.-L Lollini; C De Giovanni; M Vaccari; A Argnani; S Benini; D Maurici; P Picci; K Scotlandi

Book ID
117809037
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
119 KB
Volume
26
Category
Article
ISSN
8756-3282

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✍ Frances J. Benham; Gloria Balaban; Denise Boccelli; Harry Harris πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 799 KB

## Abstract Hep 2/5 cells, a clone of HeLa which expresses both placental‐type alkaline phosphatase and fetal intestinal alkaline phosphatase (ALP), were grown as solid tumors in nude mice. Analysis of ALP isozymes present in tumor specimens excised at intervals over a 52‐day period showed that lev