Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
✍ Scribed by Ehninger, Dan; Han, Sangyeul; Shilyansky, Carrie; Zhou, Yu; Li, Weidong; Kwiatkowski, David J; Ramesh, Vijaya; Silva, Alcino J
- Book ID
- 109933166
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 234 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm1788
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## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d
Chordomas are rare sacrococcygeal/sacral, sphenooccipital/clivus, and spinal tumors whose molecular etiology remains relatively understudied. As several anecdotal reports had described chordomas in individuals with tuberous sclerosis complex (TSC), a multisystem hamartoma syndrome, we hypothesized t