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Reversal of Human Multi-Drug Resistance Leukaemic Cells by Stemofoline Derivatives via Inhibition of P-Glycoprotein Function

✍ Scribed by Umsumarng, Sonthaya; Pitchakarn, Pornsiri; Sastraruji, Kwankamol; Yodkeeree, Supachai; Ung, Alison T.; Pyne, Stephen G.; Limtrakul, Pornngarm

Book ID
127146627
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
679 KB
Volume
116
Category
Article
ISSN
1742-7835

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## Abstract In this study, oroxylin A showed strong reversal potency in BEL7402/5‐FU cells and the reversal fold (RF) reached 4.69. Simultaneously, rhodamine‐123 accumulation assay and flow cytometry analysis demonstrated oroxylin A could increase drug accumulation. When combined with oroxylin A, 5