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Reversal of Facial Selectivity in Complex Diels—Alder Reactions.

✍ Scribed by Jacques-Alexis Funel; Louis Ricard; Joelle Prunet


Publisher
John Wiley and Sons
Year
2006
Weight
25 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract Positional and facial selectivity in Diels‐Alder reactions of several hetero‐ and carbodienophiles with (−)‐(a__S__,7__S__)‐colchicine (1) has been examined. In all cases, cycloaddition occurred with high positional selectivity at the 8,12‐positions of the alkaloid and preferentially fr